In contrast, the Dissocubes® technology employs piston-gap homogenizers. The technology was developed by Müller and colleagues (, ) and later. DissoCubes are part of Nanosuspension preparation. In which piston–gap high- pressure homogenization occurs. The main advantages of this technology. Employing piston-gap homogenizers, Müller and coworkers developed the Dissocubes technology (now belonging to Skyepharma plc) and the.

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By using postproduction diesocubes, nanosuspensions are prepared into various dosage forms. The formulation for cosmetic and nutraceutical applications, such as those discussed by Petersen in the CT technology patent, has also been successful [ 6 ].

Nanosuspension: An approach to enhance solubility of drugs

By processing the same drug with different combinative techniques, it is possible to compare the reduction effectiveness and performance of the technologies. Interestingly, in this case lower pressures had an advantage in achieving smaller drug nanocrystals.

This procedure can be carried out under controlled temperature. Homogenization methods When producing nanocrystals using homogenization methods, there are three important technologies namely: The application of nanotechnology in pharmaceutical development has great potential for dissovubes formulation of poorly water-soluble compounds.

Nanosuspension Technologies for Delivery of Poorly Soluble Drugs

The effect of these parameters on the solid state behavior and morphology of the drug, as well as on the particle size reduction effectiveness of the top-down step, was analyzed. Topical nanocrystalline silver cream suppresses inflammatory cytokines and induces apoptosis of inflammatory cells in a murine model of allergic contact dermatitis.


Pattan Department of Pharmaceutics, P.

The mechanism of action of SLR is different from cyclosporine and tacrolimus. Additionally, the SEM analysis of these glibenclamide samples revealed the formation of spherical drug particles. TBA has both a high freezing point and vapor pressure, which makes it an ideal solvent for lyophilization purposes.

Eur J Pharm Biopharm. It is more efficient and suitable than LD to quantify the contamination tecjnology nanosuspensions. Microprecipitation method for preparing submicron suspensions. Alexander von Humboldt Foundation; The conventional approaches include micronization, use of fatty solutions, use of penetration enhancer or cosolvents, surfactant dispersion method, salt formation, precipitation, etc.

Quality by design approach to understand the process of nanosuspension preparation. This article will focus on nanosized crystals in medical application.

A promising drug delivery strategy. This technique can also be used to detect and quantify particle size ranges during the production procedure [ 5688 ]. Surface modified drug nanoparticles. A wide variety of drugs processed with the combinative technologies is shown in Table 1.

Transferring micron size technolgy particles into nanoscale was the next development stage [ 2627 ]. There are apparently no products on the market that use this technology, perhaps due to the difficulty of avoiding the crystal growth.

Hancock BC, Parks M. Prednisolone was processed employing this combinative technology. This equilibrium can be shifted in case the dissolution pressure increases Figure 3and thus the saturation solubility increases.

It is the production of nanoparticle suspensions in water at room temperature. The nanonization of products, whether for medical use eg, mini robots to clean arteries [ Kazimierski ]the food industry eg, nanoencapsulated vitamins for so called functional food [ Velikov ] or the application of drugs for pharmaceutical use, is an important factor both on the economical, as well as on the medical or pharmaceutical side.


The general textbook statement is that the saturation solubility c s is a constant depending on the compound, the dissolution medium and the temperature. Some of the drugs successfully tried with pulmonary route are budesonide, ketotifen, ibuprofen, indomethacin, nifedipine, itraconazole, interleukin-2, p53 gene, leuprolide, doxorubicin, etc.

Properties of nanocrystals The main reasons for the increased dissolution velocity and thus increased bioavailability are: Nanosuspensions improve therapeutic efficiency and reduce the cost of therapy through improved dosing efficiency and smaller injection volumes.

However, the drug solutions processed with medium and high drug concentrations both sprayed with a 0. It can also be used to treat psychologically induced anorexia. Because of the high boiling point and low vapour pressure of oily fatty acids and oils, the drop in pressure is not sufficient for cavitation and thus the latter is not a determining factor dissocbues this process.

Another drawback is that this technology achieves particle sizes markedly bigger than with standard technologies. The nanocrystal technology makes the fenofibrate independent of meals.